MotoGP Second Free Practice Results Alcañiz Spain Friday September 10
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. | |||
|---|---|---|---|---|---|---|---|---|
| 1 | Jack Miller | Ducati Lenovo | 344.0 | 01:47.613 |   | |||
| 2 | Aleix Espargaro | Aprilia Gresini | 346.1 | 01:47.886 | 0.273 / 0.273 | |||
| 3 | Cal Crutchlow* | Monster Energy Yamaha | 340.7 | 01:47.897 | 0.284 / 0.011 | |||
| 4 | Johann Zarco | Pramac Racing | 346.1 | 01:47.988 | 0.375 / 0.091 | |||
| 5 | Jorge Martin | Pramac Racing | 345.0 | 01:48.023 | 0.410 / 0.035 | |||
| 6 | Francesco Bagnaia | Ducati Lenovo | 349.5 | 01:48.032 | 0.419 / 0.009 | |||
| 7 | Fabio Quartararo | Monster Energy Yamaha | 336.5 | 01:48.034 | 0.421 / 0.002 | |||
| 8 | Takaaki Nakagami | LCR Honda Idemitsu | 344.0 | 01:48.057 | 0.444 / 0.023 | |||
| 9 | Enea Bastianini | Esponsorama Racing | 344.0 | 01:48.086 | 0.473 / 0.029 | |||
| 10 | Pol Espargaro | Repsol Honda | 348.4 | 01:48.166 | 0.553 / 0.080 | |||
| 11 | Alex Rins | Suzuki Ecstar | 341.8 | 01:48.267 | 0.654 / 0.101 | |||
| 12 | Brad Binder | Red Bull KTM | 345.0 | 01:48.278 | 0.665 / 0.011 | |||
| 13 | Alex Marquez | LCR Honda Castrol | 342.9 | 01:48.314 | 0.701 / 0.036 | |||
| 14 | Danilo Petrucci | Tech 3 KTM | 338.6 | 01:48.351 | 0.738 / 0.037 | |||
| 15 | Luca Marini | Sky VR46 Esponsorama | 341.8 | 01:48.456 | 0.843 / 0.105 | |||
| 16 | Iker Lecuona | Tech 3 KTM | 339.6 | 01:48.526 | 0.913 / 0.070 | |||
| 17 | Miguel Oliveira | Red Bull KTM | 345.0 | 01:48.623 | 1.010 / 0.097 | |||
| 18 | Valentino Rossi | Petronas Yamaha | 340.7 | 01:48.649 | 1.036 / 0.026 | |||
| 19 | Maverick Viñales^ | Aprilia Gresini | 341.8 | 01:48.755 | 1.142 / 0.106 | |||
| 20 | Marc Marquez | Repsol Honda | 347.3 | 01:48.827 | 1.214 / 0.072 | |||
| 21 | Joan Mir | Suzuki Ecstar | 341.8 | 01:48.886 | 1.273 / 0.059 | |||
| 22 | Jake Dixon° | Petronas Yamaha | 336.5 | 01:49.987 | 2.374 / 1.101 | 
*Replaced former Yamaha rider Maverick Viñales for the Aragon Grand Prix
^Replaced Lorenzo Savadori for the rest of the 2021 season
°Replaced Franco Morbidelli for the Aragon Grand Prix
Note: Maverick Viñales made his debut for Aprilia after parting ways with Yamaha following his suspension from the Austrian Grand Prix
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