MotoGP Second Free Practice Results Austin United States Saturday March 28
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Jorge Martin | Aprilia Racing | 349.2 | 02:01.563 | |
| 2 | Marc Marquez | Ducati Lenovo | 343.5 | 02:01.714 | 0.151 / 0.151 |
| 3 | Francesco Bagnaia | Ducati Lenovo | 344.7 | 02:01.763 | 0.200 / 0.049 |
| 4 | Marco Bezzecchi | Aprilia Racing | 351.6 | 02:01.789 | 0.226 / 0.026 |
| 5 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 349.2 | 02:01.983 | 0.420 / 0.194 |
| 6 | Pedro Acosta | Red Bull KTM | 349.2 | 02:02.013 | 0.450 / 0.030 |
| 7 | Fermin Aldeguer | Gresini Racing | 342.4 | 02:02.132 | 0.569 / 0.119 |
| 8 | Joan Mir | Honda HRC Castrol | 345.8 | 02:02.344 | 0.781 / 0.212 |
| 9 | Alex Marquez | Gresini Racing | 349.2 | 02:02.378 | 0.815 / 0.034 |
| 10 | Raul Fernandez | Trackhouse Racing | 341.3 | 02:02.392 | 0.829 / 0.014 |
| 11 | Enea Bastianini | KTM Tech3 | 340.2 | 02:02.422 | 0.859 / 0.030 |
| 12 | Diogo Moreira | Pro Honda LCR | 343.5 | 02:02.488 | 0.925 / 0.066 |
| 13 | Brad Binder | Red Bull KTM | 349.2 | 02:02.640 | 1.077 / 0.152 |
| 14 | Luca Marini | Honda HRC Castrol | 346.9 | 02:02.720 | 1.157 / 0.080 |
| 15 | Toprak Razgatlıoğlu | Pramac Racing | 344.7 | 02:02.803 | 1.240 / 0.083 |
| 16 | Ai Ogura | Trackhouse Racing | 343.5 | 02:02.955 | 1.392 / 0.152 |
| 17 | Fabio Quartararo | Monster Energy Yamaha | 336.9 | 02:02.969 | 1.406 / 0.014 |
| 18 | Johann Zarco | Castrol Honda LCR | 346.9 | 02:03.071 | 1.508 / 0.102 |
| 19 | Franco Morbidelli | Pertamina Enduro VR46 | 345.8 | 02:03.104 | 1.541 / 0.033 |
| 20 | Alex Rins | Monster Energy Yamaha | 344.7 | 02:03.441 | 1.878 / 0.337 |
| 21 | Jack Miller | Pramac Racing | 340.2 | 02:03.460 | 1.897 / 0.019 |
Note: Red Bull KTM Tech3 rider Maverick Viñales withdrew from the United States Grand Prix following FP1 due to discomfort in his left shoulder.