MotoGP First Free Practice Results Misano Italy Friday September 11
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marc Marquez | Ducati Lenovo | 298.3 | 01:31.468 | |
| 2 | Marco Bezzecchi | Aprilia Racing | 301.6 | 01:31.528 | 0.060 / 0.060 |
| 3 | Raul Fernandez | Trackhouse Racing | 295.8 | 01:31.601 | 0.133 / 0.073 |
| 4 | Alex Marquez | Gresini Racing | 300.0 | 01:31.648 | 0.180 / 0.047 |
| 5 | Johann Zarco | Castrol Honda LCR | 299.1 | 01:31.650 | 0.182 / 0.002 |
| 6 | Pedro Acosta | Red Bull KTM | 298.3 | 01:31.678 | 0.210 / 0.028 |
| 7 | Luca Marini | Honda HRC Castrol | 300.8 | 01:31.722 | 0.254 / 0.044 |
| 8 | Jorge Martin | Aprilia Racing | 297.5 | 01:31.735 | 0.267 / 0.013 |
| 9 | Fabio Quartararo | Monster Energy Yamaha | 292.6 | 01:31.870 | 0.402 / 0.135 |
| 10 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 297.5 | 01:31.977 | 0.509 / 0.107 |
| 11 | Pol Espargaro* | KTM Tech3 | 300.0 | 01:32.005 | 0.537 / 0.028 |
| 12 | Fermin Aldeguer | Gresini Racing | 296.7 | 01:32.127 | 0.659 / 0.122 |
| 13 | Franco Morbidelli | Pertamina Enduro VR46 | 297.5 | 01:32.171 | 0.703 / 0.044 |
| 14 | Toprak Razgatlıoğlu | Pramac Racing | 292.6 | 01:32.205 | 0.737 / 0.034 |
| 15 | Enea Bastianini | KTM Tech3 | 297.5 | 01:32.221 | 0.753 / 0.016 |
| 16 | Brad Binder | Red Bull KTM | 300.0 | 01:32.229 | 0.761 / 0.008 |
| 17 | Jack Miller | Pramac Racing | 295.0 | 01:32.368 | 0.900 / 0.139 |
| 18 | Francesco Bagnaia | Ducati Lenovo | 298.3 | 01:32.461 | 0.993 / 0.093 |
| 19 | Joan Mir | Honda HRC Castrol | 296.7 | 01:32.621 | 1.153 / 0.160 |
| 20 | Diogo Moreira | Pro Honda LCR | 299.1 | 01:32.638 | 1.170 / 0.017 |
| 21 | Alex Rins | Monster Energy Yamaha | 295.8 | 01:33.322 | 1.854 / 0.684 |
*Replaced Maverick Viñales for the San Marino Grand Prix
Note: Red Bull KTM Tech3 rider Maverick Viñales (left shoulder injury recovery) and SuperFile Trackhouse's Ai Ogura (left hand injury recovery) were ruled out of the San Marino Grand Prix.