MotoGP Practice Results Misano Italy Friday September 11
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marco Bezzecchi | Aprilia Racing | 300.0 | 01:30.144 | |
| 2 | Marc Marquez | Ducati Lenovo | 299.1 | 01:30.247 | 0.103 / 0.103 |
| 3 | Alex Marquez | Gresini Racing | 299.1 | 01:30.329 | 0.185 / 0.082 |
| 4 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 297.5 | 01:30.385 | 0.241 / 0.056 |
| 5 | Franco Morbidelli | Pertamina Enduro VR46 | 297.5 | 01:30.415 | 0.271 / 0.030 |
| 6 | Pedro Acosta | Red Bull KTM | 299.1 | 01:30.488 | 0.344 / 0.073 |
| 7 | Luca Marini | Honda HRC Castrol | 298.3 | 01:30.640 | 0.496 / 0.152 |
| 8 | Johann Zarco | Castrol Honda LCR | 300.8 | 01:30.654 | 0.510 / 0.014 |
| 9 | Pol Espargaro* | KTM Tech3 | 300.8 | 01:30.674 | 0.530 / 0.020 |
| 10 | Jorge Martin | Aprilia Racing | 299.1 | 01:30.690 | 0.546 / 0.016 |
| 11 | Enea Bastianini | KTM Tech3 | 299.1 | 01:30.704 | 0.560 / 0.014 |
| 12 | Raul Fernandez | Trackhouse Racing | 295.0 | 01:30.716 | 0.572 / 0.012 |
| 13 | Fermin Aldeguer | Gresini Racing | 296.7 | 01:30.758 | 0.614 / 0.042 |
| 14 | Joan Mir | Honda HRC Castrol | 300.0 | 01:30.859 | 0.715 / 0.101 |
| 15 | Brad Binder | Red Bull KTM | 300.8 | 01:30.943 | 0.799 / 0.084 |
| 16 | Fabio Quartararo | Monster Energy Yamaha | 293.4 | 01:31.178 | 1.034 / 0.235 |
| 17 | Diogo Moreira | Pro Honda LCR | 300.8 | 01:31.263 | 1.119 / 0.085 |
| 18 | Alex Rins | Monster Energy Yamaha | 295.0 | 01:31.281 | 1.137 / 0.018 |
| 19 | Francesco Bagnaia | Ducati Lenovo | 296.7 | 01:31.459 | 1.315 / 0.178 |
| 20 | Jack Miller | Pramac Racing | 292.6 | 01:31.567 | 1.423 / 0.108 |
| 21 | Toprak Razgatlıoğlu | Pramac Racing | 294.2 | 01:32.071 | 1.927 / 0.504 |
*Replaced Maverick Viñales for the San Marino Grand Prix
Note: Red Bull KTM Tech3 rider Maverick Viñales (left shoulder injury recovery) and SuperFile Trackhouse's Ai Ogura (left hand injury recovery) were ruled out of the San Marino Grand Prix.