MotoGP Second Free Practice Results Motegi Japan Saturday October 3
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marco Bezzecchi | Aprilia Racing | 320.4 | 01:43.321 | |
| 2 | Jorge Martin | Aprilia Racing | 319.5 | 01:43.401 | 0.080 / 0.080 |
| 3 | Pedro Acosta | Red Bull KTM | 317.6 | 01:43.501 | 0.180 / 0.100 |
| 4 | Marc Marquez | Ducati Lenovo | 319.5 | 01:43.564 | 0.243 / 0.063 |
| 5 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 316.7 | 01:43.590 | 0.269 / 0.026 |
| 6 | Brad Binder | Red Bull KTM | 319.5 | 01:43.646 | 0.325 / 0.056 |
| 7 | Enea Bastianini | KTM Tech3 | 319.5 | 01:43.691 | 0.370 / 0.045 |
| 8 | Alex Marquez | Gresini Racing | 317.6 | 01:43.718 | 0.397 / 0.027 |
| 9 | Raul Fernandez | Trackhouse Racing | 316.7 | 01:43.748 | 0.427 / 0.030 |
| 10 | Fabio Quartararo | Monster Energy Yamaha | 312.1 | 01:43.749 | 0.428 / 0.001 |
| 11 | Ai Ogura | Trackhouse Racing | 324.3 | 01:43.787 | 0.466 / 0.038 |
| 12 | Francesco Bagnaia | Ducati Lenovo | 318.5 | 01:43.800 | 0.479 / 0.013 |
| 13 | Johann Zarco | Castrol Honda LCR | 320.4 | 01:43.805 | 0.484 / 0.005 |
| 14 | Diogo Moreira | Pro Honda LCR | 318.5 | 01:43.862 | 0.541 / 0.057 |
| 15 | Luca Marini | Honda HRC Castrol | 319.5 | 01:44.012 | 0.691 / 0.150 |
| 16 | Franco Morbidelli | Pertamina Enduro VR46 | 315.7 | 01:44.190 | 0.869 / 0.178 |
| 17 | Maverick Viñales | KTM Tech3 | 316.7 | 01:44.334 | 1.013 / 0.144 |
| 18 | Fermin Aldeguer | Gresini Racing | 317.6 | 01:44.489 | 1.168 / 0.155 |
| 19 | Jack Miller | Pramac Racing | 314.8 | 01:44.515 | 1.194 / 0.026 |
| 20 | Somkiat Chantra* | Honda HRC Castrol | 318.5 | 01:44.524 | 1.203 / 0.009 |
| 21 | Alex Rins | Monster Energy Yamaha | 312.1 | 01:44.883 | 1.562 / 0.359 |
| 22 | Toprak Razgatlıoğlu | Pramac Racing | 311.2 | 01:44.910 | 1.589 / 0.027 |
*Replaced Joan Mir for the Japanese Grand Prix
Note: Honda HRC's wild card rider Takaaki Nakagami was declared unfit for the Japanese Grand Prix after suffering a left collarbone fracture in a highside crash during FP1.
Honda HRC Castrol rider Joan Mir (physical health recovery) was ruled out of the Japanese Grand Prix.