MotoGP Second Free Practice Results Misano San Marino Saturday September 13
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marco Bezzecchi | Aprilia Racing | 300.8 | 01:30.624 | |
| 2 | Franco Morbidelli | Pertamina Enduro VR46 | 300.0 | 01:30.914 | 0.290 / 0.290 |
| 3 | Luca Marini | Honda HRC Castrol | 303.3 | 01:31.194 | 0.570 / 0.280 |
| 4 | Pedro Acosta | Red Bull KTM | 303.3 | 01:31.201 | 0.577 / 0.007 |
| 5 | Marc Marquez | Ducati Lenovo | 302.5 | 01:31.206 | 0.582 / 0.005 |
| 6 | Alex Marquez | Gresini Racing | 300.0 | 01:31.236 | 0.612 / 0.030 |
| 7 | Fabio Quartararo | Monster Energy Yamaha | 296.7 | 01:31.296 | 0.672 / 0.060 |
| 8 | Francesco Bagnaia | Ducati Lenovo | 300.0 | 01:31.344 | 0.720 / 0.048 |
| 9 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 298.3 | 01:31.379 | 0.755 / 0.035 |
| 10 | Fermin Aldeguer | Gresini Racing | 300.8 | 01:31.401 | 0.777 / 0.022 |
| 11 | Enea Bastianini | KTM Tech3 | 301.6 | 01:31.643 | 1.019 / 0.242 |
| 12 | Raul Fernandez | Trackhouse Racing | 296.7 | 01:31.761 | 1.137 / 0.118 |
| 13 | Jorge Martin | Aprilia Racing | 299.1 | 01:31.811 | 1.187 / 0.050 |
| 14 | Ai Ogura | Trackhouse Racing | 300.8 | 01:31.870 | 1.246 / 0.059 |
| 15 | Brad Binder | Red Bull KTM | 297.5 | 01:31.944 | 1.320 / 0.074 |
| 16 | Jack Miller | Pramac Racing | 299.1 | 01:31.950 | 1.326 / 0.006 |
| 17 | Maverick Viñales | KTM Tech3 | 295.8 | 01:32.010 | 1.386 / 0.060 |
| 18 | Alex Rins | Monster Energy Yamaha | 296.7 | 01:32.015 | 1.391 / 0.005 |
| 19 | Miguel Oliveira | Pramac Racing | 299.1 | 01:32.030 | 1.406 / 0.015 |
| 20 | Johann Zarco | Castrol Honda LCR | 300.8 | 01:32.299 | 1.675 / 0.269 |
| 21 | Augusto Fernandez* | Yamaha Factory Racing | 292.6 | 01:32.664 | 2.040 / 0.365 |
| 22 | Somkiat Chantra | Idemitsu Honda LCR | 299.1 | 01:32.871 | 2.247 / 0.207 |
*Wild card entry
Note: Honda HRC Castrol rider Joan Mir sat out Saturday's running due to neck pain suffered in a crash in Practice.