MotoGP Second Practice Results Mugello Italy Friday June 9
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Francesco Bagnaia | Ducati Lenovo | 354.0 | 01:45.436 | |
| 2 | Marco Bezzecchi | Mooney VR46 Racing | 354.0 | 01:45.499 | 0.063 / 0.063 |
| 3 | Alex Rins | LCR Honda Castrol | 354.0 | 01:45.517 | 0.081 / 0.018 |
| 4 | Brad Binder | Red Bull KTM | 358.8 | 01:45.554 | 0.118 / 0.037 |
| 5 | Jorge Martin | Pramac Racing | 360.0 | 01:45.570 | 0.134 / 0.016 |
| 6 | Enea Bastianini | Ducati Lenovo | 358.8 | 01:45.635 | 0.199 / 0.065 |
| 7 | Johann Zarco | Pramac Racing | 356.4 | 01:45.662 | 0.226 / 0.027 |
| 8 | Marc Marquez | Repsol Honda | 352.9 | 01:45.691 | 0.255 / 0.029 |
| 9 | Aleix Espargaro | Aprilia Racing | 355.2 | 01:45.784 | 0.348 / 0.093 |
| 10 | Luca Marini | Mooney VR46 Racing | 354.0 | 01:45.835 | 0.399 / 0.051 |
| 11 | Maverick Viñales | Aprilia Racing | 354.0 | 01:45.846 | 0.410 / 0.011 |
| 12 | Raul Fernandez | RNF MotoGP | 355.2 | 01:45.852 | 0.416 / 0.006 |
| 13 | Alex Marquez | Gresini Racing | 358.8 | 01:45.928 | 0.492 / 0.076 |
| 14 | Jack Miller | Red Bull KTM | 357.6 | 01:46.162 | 0.726 / 0.234 |
| 15 | Franco Morbidelli | Monster Energy Yamaha | 350.6 | 01:46.238 | 0.802 / 0.076 |
| 16 | Fabio Quartararo | Monster Energy Yamaha | 354.0 | 01:46.304 | 0.868 / 0.066 |
| 17 | Fabio Di Giannantonio | Gresini Racing | 351.7 | 01:46.547 | 1.111 / 0.243 |
| 18 | Miguel Oliveira | RNF MotoGP | 356.4 | 01:46.565 | 1.129 / 0.018 |
| 19 | Michele Pirro* | Aruba.it Racing | 357.6 | 01:46.828 | 1.392 / 0.263 |
| 20 | Augusto Fernandez | GASGAS Tech3 | 352.9 | 01:47.014 | 1.578 / 0.186 |
| 21 | Takaaki Nakagami | LCR Honda Idemitsu | 352.9 | 01:47.074 | 1.638 / 0.060 |
| 22 | Lorenzo Savadori* | Aprilia Racing | 352.9 | 01:47.833 | 2.397 / 0.759 |
| 23 | Joan Mir | Repsol Honda | 352.9 | 01:48.843 | 3.407 / 1.010 |
| 24 | Jonas Folger^ | GASGAS Tech3 | 349.5 | 01:49.160 | 3.724 / 0.317 |
*Wild card entry (2)
^Replaced Pol Espargaro for the Italian Grand Prix