MotoGP First Practice Results Mugello Italy Friday June 9
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Alex Marquez | Gresini Racing | 354.0 | 01:46.121 | |
| 2 | Fabio Quartararo | Monster Energy Yamaha | 348.3 | 01:46.208 | 0.087 / 0.087 |
| 3 | Brad Binder | Red Bull KTM | 356.4 | 01:46.225 | 0.104 / 0.017 |
| 4 | Marco Bezzecchi | Mooney VR46 Racing | 351.7 | 01:46.301 | 0.180 / 0.076 |
| 5 | Johann Zarco | Pramac Racing | 355.2 | 01:46.335 | 0.214 / 0.034 |
| 6 | Jorge Martin | Pramac Racing | 352.9 | 01:46.361 | 0.240 / 0.026 |
| 7 | Franco Morbidelli | Monster Energy Yamaha | 349.5 | 01:46.400 | 0.279 / 0.039 |
| 8 | Maverick Viñales | Aprilia Racing | 352.9 | 01:46.404 | 0.283 / 0.004 |
| 9 | Marc Marquez | Repsol Honda | 350.6 | 01:46.409 | 0.288 / 0.005 |
| 10 | Raul Fernandez | RNF MotoGP | 349.5 | 01:46.428 | 0.307 / 0.019 |
| 11 | Michele Pirro* | Aruba.it Racing | 351.7 | 01:46.488 | 0.367 / 0.060 |
| 12 | Alex Rins | LCR Honda Castrol | 348.3 | 01:46.506 | 0.385 / 0.018 |
| 13 | Takaaki Nakagami | LCR Honda Idemitsu | 350.6 | 01:46.506 | 0.385 / 0.000 |
| 14 | Jack Miller | Red Bull KTM | 352.9 | 01:46.564 | 0.443 / 0.058 |
| 15 | Enea Bastianini | Ducati Lenovo | 355.2 | 01:46.801 | 0.680 / 0.237 |
| 16 | Francesco Bagnaia | Ducati Lenovo | 351.7 | 01:46.839 | 0.718 / 0.038 |
| 17 | Fabio Di Giannantonio | Gresini Racing | 349.5 | 01:46.889 | 0.768 / 0.050 |
| 18 | Luca Marini | Mooney VR46 Racing | 351.7 | 01:46.934 | 0.813 / 0.045 |
| 19 | Augusto Fernandez | GASGAS Tech3 | 348.3 | 01:47.442 | 1.321 / 0.508 |
| 20 | Joan Mir | Repsol Honda | 351.7 | 01:47.614 | 1.493 / 0.172 |
| 21 | Miguel Oliveira | RNF MotoGP | 354.0 | 01:47.853 | 1.732 / 0.239 |
| 22 | Aleix Espargaro | Aprilia Racing | 350.6 | 01:48.102 | 1.981 / 0.249 |
| 23 | Lorenzo Savadori* | Aprilia Racing | 355.2 | 01:48.165 | 2.044 / 0.063 |
| 24 | Jonas Folger^ | GASGAS Tech3 | 343.9 | 01:48.482 | 2.361 / 0.317 |
*Wild card entry (2)
^Replaced Pol Espargaro for the Italian Grand Prix