Formula 1 First Free Practice Results Mexico City Mexico Friday October 28
| P | Driver | Team | Lap time | Laps |
| 1 | Carlos Sainz | Scuderia Ferrari | 01:20.707 | 25 |
| 2 | Charles Leclerc | Scuderia Ferrari | 01:20.753 | 20 |
| 3 | Sergio Perez | Red Bull Racing | 01:20.827 | 22 |
| 4 | Max Verstappen | Red Bull Racing | 01:20.827 | 22 |
| 5 | Lewis Hamilton | Mercedes | 01:20.849 | 17 |
| 6 | Fernando Alonso | Alpine | 01:20.899 | 26 |
| 7 | Valtteri Bottas | Alfa Romeo | 01:21.083 | 23 |
| 8 | Lando Norris | McLaren | 01:21.120 | 21 |
| 9 | Pierre Gasly | AlphaTauri | 01:21.310 | 25 |
| 10 | Sebastian Vettel | Aston Martin | 01:21.525 | 24 |
| 11 | Daniel Ricciardo | McLaren | 01:21.762 | 16 |
| 12 | Guanyu Zhou | Alfa Romeo | 01:21.820 | 20 |
| 13 | Lance Stroll | Aston Martin | 01:21.865 | 24 |
| 14 | Mick Schumacher | Haas | 01:21.952 | 22 |
| 15 | Nicholas Latifi | Williams | 01:22.912 | 20 |
| 16 | Liam Lawson* | AlphaTauri | 01:23.861 | 19 |
| 17 | Logan Sargeant^ | Williams | 01:24.246 | 22 |
| 18 | Nyck de Vries° | Mercedes | 01:24.582 | 20 |
| 19 | Jack Doohan+ | Alpine | 01:24.615 | 13 |
| 20 | Pietro Fittipaldi~ |
Haas | 01:26.766 | 9 |
*Substitute for Yuki Tsunoda
^Substitute for Alexander Albon
°Substitute for George Russell
+Substitute for Esteban Ocon
~Substitute for Kevin Magnussen