MotoGP Second Free Practice Results Misano San Marino Saturday September 7
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marco Bezzecchi | Pertamina Enduro VR46 | 299.1 | 01:31.237 | |
| 2 | Francesco Bagnaia | Ducati Lenovo | 299.1 | 01:31.332 | 0.095 / 0.095 |
| 3 | Jorge Martin | Pramac Racing | 298.3 | 01:31.385 | 0.148 / 0.053 |
| 4 | Enea Bastianini | Ducati Lenovo | 295.8 | 01:31.390 | 0.153 / 0.005 |
| 5 | Franco Morbidelli | Pramac Racing | 298.3 | 01:31.394 | 0.157 / 0.004 |
| 6 | Pol Espargaro* | Red Bull KTM | 299.1 | 01:31.568 | 0.331 / 0.174 |
| 7 | Marc Marquez | Gresini Racing | 295.8 | 01:31.590 | 0.353 / 0.022 |
| 8 | Pedro Acosta | GASGAS Tech3 | 296.7 | 01:31.636 | 0.399 / 0.046 |
| 9 | Alex Marquez | Gresini Racing | 298.3 | 01:31.827 | 0.590 / 0.191 |
| 10 | Aleix Espargaro | Aprilia Racing | 299.1 | 01:31.833 | 0.596 / 0.006 |
| 11 | Fabio Quartararo | Monster Energy Yamaha | 291.8 | 01:31.834 | 0.597 / 0.001 |
| 12 | Brad Binder | Red Bull KTM | 297.5 | 01:31.840 | 0.603 / 0.006 |
| 13 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 291.8 | 01:31.911 | 0.674 / 0.071 |
| 14 | Miguel Oliveira | Trackhouse Racing | 296.7 | 01:31.950 | 0.713 / 0.039 |
| 15 | Jack Miller | Red Bull KTM | 297.5 | 01:31.995 | 0.758 / 0.045 |
| 16 | Maverick Viñales | Aprilia Racing | 296.7 | 01:32.037 | 0.800 / 0.042 |
| 17 | Alex Rins | Monster Energy Yamaha | 293.4 | 01:32.175 | 0.938 / 0.138 |
| 18 | Augusto Fernandez | GASGAS Tech3 | 296.7 | 01:32.232 | 0.995 / 0.057 |
| 19 | Takaaki Nakagami | LCR Honda Idemitsu | 293.4 | 01:32.405 | 1.168 / 0.173 |
| 20 | Johann Zarco | LCR Honda Castrol | 293.4 | 01:32.490 | 1.253 / 0.085 |
| 21 | Luca Marini | Repsol Honda | 295.8 | 01:32.550 | 1.313 / 0.060 |
| 22 | Raul Fernandez | Trackhouse Racing | 295.0 | 01:32.848 | 1.611 / 0.298 |
| 23 | Stefan Bradl* | HRC Team | 294.2 | 01:33.615 | 2.378 / 0.767 |
*Wild card entry (2)
Note: Repsol Honda rider Joan Mir withdrew from the San Marino Grand Prix due to illness.
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