MotoGP Second Free Practice Results Portimão Portugal Friday April 22
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Pol Espargaro | Repsol Honda | 328.2 | 01:50.707 | |
| 2 | Marc Marquez | Repsol Honda | 327.2 | 01:51.318 | 0.611 / 0.611 |
| 3 | Andrea Dovizioso | WithU Yamaha RNF | 322.3 | 01:51.756 | 1.049 / 0.438 |
| 4 | Francesco Bagnaia | Ducati Lenovo | 326.2 | 01:51.789 | 1.082 / 0.033 |
| 5 | Jorge Martin | Pramac Racing | 325.3 | 01:51.794 | 1.087 / 0.005 |
| 6 | Alex Marquez | LCR Honda Castrol | 330.2 | 01:51.874 | 1.167 / 0.080 |
| 7 | Franco Morbidelli | Monster Energy Yamaha | 317.6 | 01:51.911 | 1.204 / 0.037 |
| 8 | Maverick Viñales | Aprilia Racing | 331.2 | 01:51.925 | 1.218 / 0.014 |
| 9 | Takaaki Nakagami | LCR Honda Idemitsu | 329.2 | 01:52.046 | 1.339 / 0.121 |
| 10 | Miguel Oliveira | Red Bull KTM | 324.3 | 01:52.100 | 1.393 / 0.054 |
| 11 | Joan Mir | Suzuki Ecstar | 330.2 | 01:52.306 | 1.599 / 0.206 |
| 12 | Johann Zarco | Pramac Racing | 329.2 | 01:52.320 | 1.613 / 0.014 |
| 13 | Fabio Quartararo | Monster Energy Yamaha | 325.3 | 01:52.534 | 1.827 / 0.214 |
| 14 | Enea Bastianini | Gresini Racing | 331.2 | 01:52.582 | 1.875 / 0.048 |
| 15 | Remy Gardner | Tech 3 KTM | 322.3 | 01:52.965 | 2.258 / 0.383 |
| 16 | Marco Bezzecchi | Mooney VR46 Racing | 324.3 | 01:53.003 | 2.296 / 0.038 |
| 17 | Jack Miller | Ducati Lenovo | 326.2 | 01:53.103 | 2.396 / 0.100 |
| 18 | Aleix Espargaro | Aprilia Racing | 329.2 | 01:53.302 | 2.595 / 0.199 |
| 19 | Brad Binder | Red Bull KTM | 325.3 | 01:53.527 | 2.820 / 0.225 |
| 20 | Alex Rins | Suzuki Ecstar | 329.2 | 01:54.327 | 3.620 / 0.800 |
| 21 | Darryn Binder | WithU Yamaha RNF | 322.3 | 01:54.385 | 3.678 / 0.058 |
| 22 | Lorenzo Savadori* | Aprilia Racing | 326.2 | 01:54.876 | 4.169 / 0.491 |
| 23 | Fabio Di Giannantonio | Gresini Racing | 324.3 | 01:55.571 | 4.864 / 0.695 |
| 24 | Raul Fernandez | Tech 3 KTM | 318.5 | 01:56.330 | 5.623 / 0.759 |
| 25 | Luca Marini | Mooney VR46 Racing | 318.5 | 01:58.592 | 7.885 / 2.262 |
*Wild card entry
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