MotoGP First Free Practice Results Alcañiz Aragón Friday September 16
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Aleix Espargaro | Aprilia Racing | 344.0 | 01:48.686 | |
| 2 | Francesco Bagnaia | Ducati Lenovo | 349.5 | 01:48.698 | 0.012 / 0.012 |
| 3 | Alex Rins | Suzuki Ecstar | 345.0 | 01:48.775 | 0.089 / 0.077 |
| 4 | Takaaki Nakagami | LCR Honda Idemitsu | 341.8 | 01:48.862 | 0.176 / 0.087 |
| 5 | Johann Zarco | Pramac Racing | 345.0 | 01:48.882 | 0.196 / 0.020 |
| 6 | Enea Bastianini | Gresini Racing | 345.0 | 01:48.891 | 0.205 / 0.009 |
| 7 | Miguel Oliveira | Red Bull KTM | 347.3 | 01:49.005 | 0.319 / 0.114 |
| 8 | Fabio Quartararo | Monster Energy Yamaha | 341.8 | 01:49.085 | 0.399 / 0.080 |
| 9 | Franco Morbidelli | Monster Energy Yamaha | 340.7 | 01:49.088 | 0.402 / 0.003 |
| 10 | Luca Marini | Mooney VR46 Racing | 342.9 | 01:49.170 | 0.484 / 0.082 |
| 11 | Marc Marquez | Repsol Honda | 342.9 | 01:49.207 | 0.521 / 0.037 |
| 12 | Jorge Martin | Pramac Racing | 344.0 | 01:49.320 | 0.634 / 0.113 |
| 13 | Jack Miller | Ducati Lenovo | 349.5 | 01:49.322 | 0.636 / 0.002 |
| 14 | Marco Bezzecchi | Mooney VR46 Racing | 346.1 | 01:49.349 | 0.663 / 0.027 |
| 15 | Maverick Viñales | Aprilia Racing | 344.0 | 01:49.357 | 0.671 / 0.008 |
| 16 | Cal Crutchlow* | WithU Yamaha RNF | 347.3 | 01:49.392 | 0.706 / 0.035 |
| 17 | Joan Mir | Suzuki Ecstar | 344.0 | 01:49.447 | 0.761 / 0.055 |
| 18 | Alex Marquez | LCR Honda Castrol | 344.0 | 01:49.490 | 0.804 / 0.043 |
| 19 | Pol Espargaro | Repsol Honda | 340.7 | 01:49.515 | 0.829 / 0.025 |
| 20 | Brad Binder | Red Bull KTM | 347.3 | 01:49.642 | 0.956 / 0.127 |
| 21 | Fabio Di Giannantonio | Gresini Racing | 344.0 | 01:49.850 | 1.164 / 0.208 |
| 22 | Remy Gardner | Tech 3 KTM | 338.6 | 01:50.249 | 1.563 / 0.399 |
| 23 | Raul Fernandez | Tech 3 KTM | 340.7 | 01:50.312 | 1.626 / 0.063 |
| 24 | Darryn Binder | WithU Yamaha RNF | 342.9 | 01:50.370 | 1.684 / 0.058 |
*Replaced Andrea Dovizioso at WithU Yamaha RNF MotoGP for the remainder of the 2022 season
Note: Italy's Andrea Dovizioso retired from MotoGP following the San Marino Grand Prix.