MotoGP Second Free Practice Results Alcañiz Aragón Friday September 16
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Jorge Martin | Pramac Racing | 346.1 | 01:47.402 | |
| 2 | Fabio Quartararo | Monster Energy Yamaha | 344.0 | 01:47.476 | 0.074 / 0.074 |
| 3 | Johann Zarco | Pramac Racing | 344.0 | 01:47.509 | 0.107 / 0.033 |
| 4 | Enea Bastianini | Gresini Racing | 349.5 | 01:47.583 | 0.181 / 0.074 |
| 5 | Francesco Bagnaia | Ducati Lenovo | 349.5 | 01:47.639 | 0.237 / 0.056 |
| 6 | Alex Rins | Suzuki Ecstar | 344.0 | 01:47.665 | 0.263 / 0.026 |
| 7 | Maverick Viñales | Aprilia Racing | 344.0 | 01:47.678 | 0.276 / 0.013 |
| 8 | Marc Marquez | Repsol Honda | 346.1 | 01:47.761 | 0.359 / 0.083 |
| 9 | Jack Miller | Ducati Lenovo | 346.1 | 01:47.800 | 0.398 / 0.039 |
| 10 | Luca Marini | Mooney VR46 Racing | 346.1 | 01:47.893 | 0.491 / 0.093 |
| 11 | Takaaki Nakagami | LCR Honda Idemitsu | 340.7 | 01:47.911 | 0.509 / 0.018 |
| 12 | Brad Binder | Red Bull KTM | 345.0 | 01:47.912 | 0.510 / 0.001 |
| 13 | Aleix Espargaro | Aprilia Racing | 344.0 | 01:47.951 | 0.549 / 0.039 |
| 14 | Franco Morbidelli | Monster Energy Yamaha | 344.0 | 01:48.002 | 0.600 / 0.051 |
| 15 | Miguel Oliveira | Red Bull KTM | 342.9 | 01:48.042 | 0.640 / 0.040 |
| 16 | Fabio Di Giannantonio | Gresini Racing | 344.0 | 01:48.229 | 0.827 / 0.187 |
| 17 | Marco Bezzecchi | Mooney VR46 Racing | 345.0 | 01:48.475 | 1.073 / 0.246 |
| 18 | Alex Marquez | LCR Honda Castrol | 340.7 | 01:48.521 | 1.119 / 0.046 |
| 19 | Cal Crutchlow* | WithU Yamaha RNF | 344.0 | 01:48.531 | 1.129 / 0.010 |
| 20 | Darryn Binder | WithU Yamaha RNF | 344.0 | 01:48.618 | 1.216 / 0.087 |
| 21 | Joan Mir | Suzuki Ecstar | 344.0 | 01:48.621 | 1.219 / 0.003 |
| 22 | Raul Fernandez | Tech 3 KTM | 345.0 | 01:48.688 | 1.286 / 0.067 |
| 23 | Pol Espargaro | Repsol Honda | 345.0 | 01:48.743 | 1.341 / 0.055 |
| 24 | Remy Gardner | Tech 3 KTM | 337.5 | 01:48.752 | 1.350 / 0.009 |
*Replaced Andrea Dovizioso at WithU Yamaha RNF MotoGP for the remainder of the 2022 season
Note: Italy's Andrea Dovizioso retired from MotoGP following the San Marino Grand Prix.