Formula 1 Second Free Practice Results Mexico City Mexico Friday October 28
| P | Driver | Team | Lap time | Laps |
| 1 | George Russell | Mercedes | 01:19.970 | 32 |
| 2 | Yuki Tsunoda | AlphaTauri | 01:20.798 | 30 |
| 3 | Esteban Ocon | Alpine | 01:21.177 | 31 |
| 4 | Lewis Hamilton | Mercedes | 01:21.509 | 32 |
| 5 | Sergio Perez | Red Bull Racing | 01:21.579 | 34 |
| 6 | Max Verstappen | Red Bull Racing | 01:21.588 | 34 |
| 7 | Charles Leclerc | Scuderia Ferrari | 01:21.618 | 13 |
| 8 | Carlos Sainz | Scuderia Ferrari | 01:21.693 | 34 |
| 9 | Valtteri Bottas | Alfa Romeo | 01:21.993 | 36 |
| 10 | Pierre Gasly | AlphaTauri | 01:22.104 | 36 |
| 11 | Fernando Alonso | Alpine | 01:22.337 | 31 |
| 12 | Sebastian Vettel | Aston Martin | 01:22.371 | 32 |
| 13 | Alexander Albon | Williams | 01:22.447 | 24 |
| 14 | Lando Norris | McLaren | 01:22.738 | 31 |
| 15 | Daniel Ricciardo | McLaren | 01:22.763 | 27 |
| 16 | Lance Stroll | Aston Martin | 01:22.840 | 23 |
| 17 | Mick Schumacher | Haas | 01:22.879 | 31 |
| 18 | Kevin Magnussen | Haas | 01:23.316 | 21 |
| 19 | Nicholas Latifi | Williams | 01:23.320 | 34 |
| 20 | Guanyu Zhou | Alfa Romeo | 01:23.369 | 34 |
Note: Pirelli's 2023 prototype tyres were available for teams to test during FP2.