MotoGP Second Practice Results Termas de Rio Hondo Argentina Friday March 31
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Aleix Espargaro | Aprilia Racing | 335.3 | 01:38.518 | |
| 2 | Maverick Viñales | Aprilia Racing | 338.1 | 01:38.680 | 0.162 / 0.162 |
| 3 | Marco Bezzecchi | Mooney VR46 Racing | 335.3 | 01:38.767 | 0.249 / 0.087 |
| 4 | Luca Marini | Mooney VR46 Racing | 335.3 | 01:38.833 | 0.315 / 0.066 |
| 5 | Johann Zarco | Pramac Racing | 334.4 | 01:38.909 | 0.391 / 0.076 |
| 6 | Francesco Bagnaia | Ducati Lenovo | 336.2 | 01:38.944 | 0.426 / 0.035 |
| 7 | Jorge Martin | Pramac Racing | 336.2 | 01:39.006 | 0.488 / 0.062 |
| 8 | Takaaki Nakagami | LCR Honda Idemitsu | 330.0 | 01:39.071 | 0.553 / 0.065 |
| 9 | Franco Morbidelli | Monster Energy Yamaha | 331.8 | 01:39.080 | 0.562 / 0.009 |
| 10 | Alex Rins | LCR Honda Castrol | 334.4 | 01:39.117 | 0.599 / 0.037 |
| 11 | Alex Marquez | Gresini Racing | 335.3 | 01:39.184 | 0.666 / 0.067 |
| 12 | Brad Binder | Red Bull KTM | 332.7 | 01:39.202 | 0.684 / 0.018 |
| 13 | Joan Mir | Repsol Honda | 330.9 | 01:39.237 | 0.719 / 0.035 |
| 14 | Fabio Quartararo | Monster Energy Yamaha | 334.4 | 01:39.264 | 0.746 / 0.027 |
| 15 | Fabio Di Giannantonio | Gresini Racing | 332.7 | 01:39.288 | 0.770 / 0.024 |
| 16 | Jack Miller | Red Bull KTM | 332.7 | 01:39.376 | 0.858 / 0.088 |
| 17 | Augusto Fernandez | GASGAS Tech3 | 331.8 | 01:39.561 | 1.043 / 0.185 |
| 18 | Raul Fernandez | RNF MotoGP | 333.6 | 01:39.575 | 1.057 / 0.014 |
Note: Marc Marquez (Honda), Miguel Oliveira (RNF MotoGP), Enea Bastianini (Ducati), and Pol Espargaro (GASGAS Tech3) were all ruled out for the Argentinian Grand Prix due to injuries.