MotoGP Second Practice Results Austin United States Friday April 14
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Jorge Martin | Pramac Racing | 340.6 | 02:02.178 | |
| 2 | Francesco Bagnaia | Ducati Lenovo | 340.6 | 02:02.241 | 0.063 / 0.063 |
| 3 | Alex Rins | LCR Honda Castrol | 341.7 | 02:02.395 | 0.217 / 0.154 |
| 4 | Luca Marini | Mooney VR46 Racing | 342.8 | 02:02.416 | 0.238 / 0.021 |
| 5 | Alex Marquez | Gresini Racing | 339.6 | 02:02.682 | 0.504 / 0.266 |
| 6 | Maverick Viñales | Aprilia Racing | 341.7 | 02:02.717 | 0.539 / 0.035 |
| 7 | Fabio Quartararo | Monster Energy Yamaha | 337.5 | 02:02.721 | 0.543 / 0.004 |
| 8 | Brad Binder | Red Bull KTM | 343.9 | 02:02.735 | 0.557 / 0.014 |
| 9 | Aleix Espargaro | Aprilia Racing | 341.7 | 02:02.765 | 0.587 / 0.030 |
| 10 | Jack Miller | Red Bull KTM | 339.6 | 02:02.841 | 0.663 / 0.076 |
| 11 | Marco Bezzecchi | Mooney VR46 Racing | 342.8 | 02:02.878 | 0.700 / 0.037 |
| 12 | Joan Mir | Repsol Honda | 338.5 | 02:02.904 | 0.726 / 0.026 |
| 13 | Takaaki Nakagami | LCR Honda Idemitsu | 335.4 | 02:03.208 | 1.030 / 0.304 |
| 14 | Johann Zarco | Pramac Racing | 338.5 | 02:03.329 | 1.151 / 0.121 |
| 15 | Miguel Oliveira | RNF MotoGP | 339.6 | 02:03.340 | 1.162 / 0.011 |
| 16 | Franco Morbidelli | Monster Energy Yamaha | 338.5 | 02:03.443 | 1.265 / 0.103 |
| 17 | Michele Pirro^ | Ducati Lenovo | 340.6 | 02:03.685 | 1.507 / 0.242 |
| 18 | Raul Fernandez | RNF MotoGP | 338.5 | 02:03.690 | 1.512 / 0.005 |
| 19 | Fabio Di Giannantonio | Gresini Racing | 339.6 | 02:04.079 | 1.901 / 0.389 |
| 20 | Stefan Bradl* | Repsol Honda | 333.3 | 02:04.129 | 1.951 / 0.050 |
| 21 | Augusto Fernandez | GASGAS Tech3 | 337.5 | 02:04.561 | 2.383 / 0.432 |
| 22 | Jonas Folger° | GASGAS Tech3 | 334.3 | 02:06.529 | 4.351 / 1.968 |
*Replaced Marc Marquez for the United States Grand Prix
^Replaced Enea Bastianini for the United States Grand Prix
°Replaced Pol Espargaro for the United States Grand Prix