MotoGP First Free Practice Results Misano San Marino Friday September 8
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Michele Pirro* | Aruba.it Racing | 296.7 | 01:31.909 | |
| 2 | Luca Marini | Mooney VR46 Racing | 297.5 | 01:32.024 | 0.115 / 0.115 |
| 3 | Jorge Martin | Pramac Racing | 299.1 | 01:32.066 | 0.157 / 0.042 |
| 4 | Marco Bezzecchi | Mooney VR46 Racing | 300.0 | 01:32.090 | 0.181 / 0.024 |
| 5 | Raul Fernandez | RNF MotoGP | 298.3 | 01:32.227 | 0.318 / 0.137 |
| 6 | Dani Pedrosa* | Red Bull KTM | 300.8 | 01:32.250 | 0.341 / 0.023 |
| 7 | Maverick Viñales | Aprilia Racing | 298.3 | 01:32.275 | 0.366 / 0.025 |
| 8 | Johann Zarco | Pramac Racing | 298.3 | 01:32.301 | 0.392 / 0.026 |
| 9 | Aleix Espargaro | Aprilia Racing | 298.3 | 01:32.327 | 0.418 / 0.026 |
| 10 | Alex Marquez | Gresini Racing | 297.5 | 01:32.349 | 0.440 / 0.022 |
| 11 | Brad Binder | Red Bull KTM | 298.3 | 01:32.390 | 0.481 / 0.041 |
| 12 | Franco Morbidelli | Monster Energy Yamaha | 294.2 | 01:32.395 | 0.486 / 0.005 |
| 13 | Pol Espargaro | GASGAS Tech3 | 300.0 | 01:32.404 | 0.495 / 0.009 |
| 14 | Jack Miller | Red Bull KTM | 297.5 | 01:32.509 | 0.600 / 0.105 |
| 15 | Fabio Quartararo | Monster Energy Yamaha | 295.0 | 01:32.510 | 0.601 / 0.001 |
| 16 | Stefan Bradl* | HRC Team | 295.8 | 01:32.538 | 0.629 / 0.028 |
| 17 | Fabio Di Giannantonio | Gresini Racing | 294.2 | 01:32.554 | 0.645 / 0.016 |
| 18 | Miguel Oliveira | RNF MotoGP | 300.8 | 01:32.559 | 0.650 / 0.005 |
| 19 | Takaaki Nakagami | LCR Honda Idemitsu | 295.0 | 01:32.571 | 0.662 / 0.012 |
| 20 | Francesco Bagnaia | Ducati Lenovo | 300.0 | 01:32.599 | 0.690 / 0.028 |
| 21 | Marc Marquez | Repsol Honda | 295.8 | 01:32.674 | 0.765 / 0.075 |
| 22 | Augusto Fernandez | GASGAS Tech3 | 295.0 | 01:33.201 | 1.292 / 0.527 |
| 23 | Joan Mir | Repsol Honda | 295.0 | 01:33.228 | 1.319 / 0.027 |
| 24 | Takumi Takahashi^ | LCR Honda Castrol | 288.0 | 01:37.894 | 5.985 / 4.666 |
*Wild card entry (3)
^Replaced Alex Rins for the San Marino Grand Prix
Note: Ducati Lenovo rider Enea Bastianini did not take part in the San Marino Grand Prix due to injuries he suffered in Catalonia.