MotoGP Practice Results Misano Italy Friday September 8
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marco Bezzecchi | Mooney VR46 Racing | 300.8 | 01:30.846 | |
| 2 | Maverick Viñales | Aprilia Racing | 298.3 | 01:30.972 | 0.126 / 0.126 |
| 3 | Dani Pedrosa* | Red Bull KTM | 303.3 | 01:31.101 | 0.255 / 0.129 |
| 4 | Jorge Martin | Pramac Racing | 298.3 | 01:31.177 | 0.331 / 0.076 |
| 5 | Luca Marini | Mooney VR46 Racing | 298.3 | 01:31.187 | 0.341 / 0.010 |
| 6 | Marc Marquez | Repsol Honda | 297.5 | 01:31.217 | 0.371 / 0.030 |
| 7 | Francesco Bagnaia | Ducati Lenovo | 298.3 | 01:31.220 | 0.374 / 0.003 |
| 8 | Alex Marquez | Gresini Racing | 295.0 | 01:31.247 | 0.401 / 0.027 |
| 9 | Brad Binder | Red Bull KTM | 300.8 | 01:31.256 | 0.410 / 0.009 |
| 10 | Raul Fernandez | RNF MotoGP | 297.5 | 01:31.536 | 0.690 / 0.280 |
| 11 | Pol Espargaro | GASGAS Tech3 | 300.0 | 01:31.560 | 0.714 / 0.024 |
| 12 | Aleix Espargaro | Aprilia Racing | 298.3 | 01:31.619 | 0.773 / 0.059 |
| 13 | Fabio Quartararo | Monster Energy Yamaha | 295.0 | 01:31.644 | 0.798 / 0.025 |
| 14 | Franco Morbidelli | Monster Energy Yamaha | 295.0 | 01:31.710 | 0.864 / 0.066 |
| 15 | Stefan Bradl* | HRC Team | 296.7 | 01:31.715 | 0.869 / 0.005 |
| 16 | Michele Pirro* | Aruba.it Racing | 295.8 | 01:31.743 | 0.897 / 0.028 |
| 17 | Jack Miller | Red Bull KTM | 297.5 | 01:31.781 | 0.935 / 0.038 |
| 18 | Johann Zarco | Pramac Racing | 297.5 | 01:31.785 | 0.939 / 0.004 |
| 19 | Fabio Di Giannantonio | Gresini Racing | 294.2 | 01:31.821 | 0.975 / 0.036 |
| 20 | Takaaki Nakagami | LCR Honda Idemitsu | 295.8 | 01:32.107 | 1.261 / 0.286 |
| 21 | Joan Mir | Repsol Honda | 297.5 | 01:32.141 | 1.295 / 0.034 |
| 22 | Miguel Oliveira | RNF MotoGP | 299.1 | 01:32.354 | 1.508 / 0.213 |
| 23 | Augusto Fernandez | GASGAS Tech3 | 292.6 | 01:32.613 | 1.767 / 0.259 |
| 24 | Takumi Takahashi^ | LCR Honda Castrol | 291.1 | 01:35.886 | 5.040 / 3.273 |
*Wild card entry (3)
^Replaced Alex Rins for the San Marino Grand Prix
Note: Ducati Lenovo rider Enea Bastianini did not take part in the San Marino Grand Prix due to injuries he suffered in Catalonia.