MotoGP Second Free Practice Results Misano San Marino Saturday September 9
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Jorge Martin | Pramac Racing | 305.0 | 01:31.803 | |
| 2 | Michele Pirro* | Aruba.it Racing | 296.7 | 01:32.169 | 0.366 / 0.366 |
| 3 | Luca Marini | Mooney VR46 Racing | 300.0 | 01:32.208 | 0.405 / 0.039 |
| 4 | Francesco Bagnaia | Ducati Lenovo | 300.0 | 01:32.227 | 0.424 / 0.019 |
| 5 | Maverick Viñales | Aprilia Racing | 299.1 | 01:32.246 | 0.443 / 0.019 |
| 6 | Alex Marquez | Gresini Racing | 300.0 | 01:32.277 | 0.474 / 0.031 |
| 7 | Brad Binder | Red Bull KTM | 301.6 | 01:32.297 | 0.494 / 0.020 |
| 8 | Marc Marquez | Repsol Honda | 296.7 | 01:32.299 | 0.496 / 0.002 |
| 9 | Miguel Oliveira | RNF MotoGP | 302.5 | 01:32.327 | 0.524 / 0.028 |
| 10 | Raul Fernandez | RNF MotoGP | 298.3 | 01:32.345 | 0.542 / 0.018 |
| 11 | Fabio Di Giannantonio | Gresini Racing | 297.5 | 01:32.354 | 0.551 / 0.009 |
| 12 | Fabio Quartararo | Monster Energy Yamaha | 297.5 | 01:32.367 | 0.564 / 0.013 |
| 13 | Jack Miller | Red Bull KTM | 299.1 | 01:32.384 | 0.581 / 0.017 |
| 14 | Dani Pedrosa* | Red Bull KTM | 303.3 | 01:32.457 | 0.654 / 0.073 |
| 15 | Pol Espargaro | GASGAS Tech3 | 300.0 | 01:32.482 | 0.679 / 0.025 |
| 16 | Augusto Fernandez | GASGAS Tech3 | 296.7 | 01:32.492 | 0.689 / 0.010 |
| 17 | Marco Bezzecchi | Mooney VR46 Racing | 302.5 | 01:32.507 | 0.704 / 0.015 |
| 18 | Aleix Espargaro | Aprilia Racing | 297.5 | 01:32.513 | 0.710 / 0.006 |
| 19 | Johann Zarco | Pramac Racing | 298.3 | 01:32.530 | 0.727 / 0.017 |
| 20 | Takaaki Nakagami | LCR Honda Idemitsu | 299.1 | 01:32.709 | 0.906 / 0.179 |
| 21 | Joan Mir | Repsol Honda | 297.5 | 01:32.832 | 1.029 / 0.123 |
| 22 | Franco Morbidelli | Monster Energy Yamaha | 297.5 | 01:33.003 | 1.200 / 0.171 |
| 23 | Stefan Bradl* | HRC Team | 297.5 | 01:33.011 | 1.208 / 0.008 |
| 24 | Takumi Takahashi^ | LCR Honda Castrol | 291.8 | 01:36.989 | 5.186 / 3.978 |
*Wild card entry (3)
^Replaced Alex Rins for the San Marino Grand Prix
Note: Ducati Lenovo rider Enea Bastianini did not take part in the San Marino Grand Prix due to injuries he suffered in Catalonia.