MotoGP Second Free Practice Results Cheste Spain Saturday November 25
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marco Bezzecchi | Mooney VR46 Racing | 332.1 | 01:30.167 | |
| 2 | Alex Marquez | Gresini Racing | 327.4 | 01:30.186 | 0.019 / 0.019 |
| 3 | Francesco Bagnaia | Ducati Lenovo | 330.5 | 01:30.193 | 0.026 / 0.007 |
| 4 | Marc Marquez | Repsol Honda | 325.8 | 01:30.213 | 0.046 / 0.020 |
| 5 | Fabio Quartararo | Monster Energy Yamaha | 325.8 | 01:30.217 | 0.050 / 0.004 |
| 6 | Jorge Martin | Pramac Racing | 333.7 | 01:30.272 | 0.105 / 0.055 |
| 7 | Brad Binder | Red Bull KTM | 330.5 | 01:30.274 | 0.107 / 0.002 |
| 8 | Maverick Viñales | Aprilia Racing | 330.5 | 01:30.314 | 0.147 / 0.040 |
| 9 | Raul Fernandez | RNF MotoGP | 327.4 | 01:30.330 | 0.163 / 0.016 |
| 10 | Fabio Di Giannantonio | Gresini Racing | 325.8 | 01:30.403 | 0.236 / 0.073 |
| 11 | Johann Zarco | Pramac Racing | 330.5 | 01:30.445 | 0.278 / 0.042 |
| 12 | Enea Bastianini | Ducati Lenovo | 330.5 | 01:30.482 | 0.315 / 0.037 |
| 13 | Franco Morbidelli | Monster Energy Yamaha | 328.9 | 01:30.587 | 0.420 / 0.105 |
| 14 | Aleix Espargaro | Aprilia Racing | 327.4 | 01:30.600 | 0.433 / 0.013 |
| 15 | Augusto Fernandez | GASGAS Tech3 | 324.3 | 01:30.614 | 0.447 / 0.014 |
| 16 | Luca Marini | Mooney VR46 Racing | 328.9 | 01:30.701 | 0.534 / 0.087 |
| 17 | Jack Miller | Red Bull KTM | 328.9 | 01:30.702 | 0.535 / 0.001 |
| 18 | Takaaki Nakagami | LCR Honda Idemitsu | 325.8 | 01:30.821 | 0.654 / 0.119 |
| 19 | Pol Espargaro | GASGAS Tech3 | 328.9 | 01:30.891 | 0.724 / 0.070 |
| 20 | Alex Rins | LCR Honda Castrol | 327.4 | 01:30.970 | 0.803 / 0.079 |
| 21 | Lorenzo Savadori* | RNF MotoGP | 324.3 | 01:31.769 | 1.602 / 0.799 |
*Replaced Miguel Oliveira for the Valencia Grand Prix
Note: Repsol Honda rider Joan Mir was declared unfit for the Valencia Grand Prix following a medical check prior to FP2.