MotoGP First Free Practice Results Misano San Marino Friday September 6
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Jorge Martin | Pramac Racing | 296.7 | 01:31.707 | |
| 2 | Marc Marquez | Gresini Racing | 295.0 | 01:31.744 | 0.037 / 0.037 |
| 3 | Pol Espargaro* | Red Bull KTM | 297.5 | 01:31.920 | 0.213 / 0.176 |
| 4 | Franco Morbidelli | Pramac Racing | 295.0 | 01:31.949 | 0.242 / 0.029 |
| 5 | Fabio Quartararo | Monster Energy Yamaha | 294.2 | 01:31.976 | 0.269 / 0.027 |
| 6 | Aleix Espargaro | Aprilia Racing | 295.0 | 01:32.098 | 0.391 / 0.122 |
| 7 | Brad Binder | Red Bull KTM | 297.5 | 01:32.135 | 0.428 / 0.037 |
| 8 | Francesco Bagnaia | Ducati Lenovo | 295.0 | 01:32.169 | 0.462 / 0.034 |
| 9 | Maverick Viñales | Aprilia Racing | 294.2 | 01:32.286 | 0.579 / 0.117 |
| 10 | Pedro Acosta | GASGAS Tech3 | 301.6 | 01:32.354 | 0.647 / 0.068 |
| 11 | Jack Miller | Red Bull KTM | 297.5 | 01:32.426 | 0.719 / 0.072 |
| 12 | Augusto Fernandez | GASGAS Tech3 | 296.7 | 01:32.453 | 0.746 / 0.027 |
| 13 | Enea Bastianini | Ducati Lenovo | 295.8 | 01:32.468 | 0.761 / 0.015 |
| 14 | Johann Zarco | LCR Honda Castrol | 296.7 | 01:32.486 | 0.779 / 0.018 |
| 15 | Marco Bezzecchi | Pertamina Enduro VR46 | 299.1 | 01:32.595 | 0.888 / 0.109 |
| 16 | Alex Marquez | Gresini Racing | 294.2 | 01:32.616 | 0.909 / 0.021 |
| 17 | Alex Rins | Monster Energy Yamaha | 295.0 | 01:32.622 | 0.915 / 0.006 |
| 18 | Luca Marini | Repsol Honda | 295.8 | 01:32.824 | 1.117 / 0.202 |
| 19 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 291.1 | 01:33.033 | 1.326 / 0.209 |
| 20 | Takaaki Nakagami | LCR Honda Idemitsu | 293.4 | 01:33.046 | 1.339 / 0.013 |
| 21 | Raul Fernandez | Trackhouse Racing | 293.4 | 01:33.163 | 1.456 / 0.117 |
| 22 | Miguel Oliveira | Trackhouse Racing | 295.8 | 01:33.267 | 1.560 / 0.104 |
| 23 | Stefan Bradl* | HRC Team | 291.8 | 01:34.400 | 2.693 / 1.133 |
*Wild card entry (2)
Note: Repsol Honda rider Joan Mir withdrew from the San Marino Grand Prix due to illness.