MotoGP Practice Results Misano San Marino Friday September 6
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Francesco Bagnaia | Ducati Lenovo | 296.7 | 01:30.685 | |
| 2 | Marc Marquez | Gresini Racing | 297.5 | 01:30.870 | 0.185 / 0.185 |
| 3 | Jorge Martin | Pramac Racing | 296.7 | 01:30.966 | 0.281 / 0.096 |
| 4 | Franco Morbidelli | Pramac Racing | 297.5 | 01:30.967 | 0.282 / 0.001 |
| 5 | Enea Bastianini | Ducati Lenovo | 296.7 | 01:31.067 | 0.382 / 0.100 |
| 6 | Pedro Acosta | GASGAS Tech3 | 298.3 | 01:31.203 | 0.518 / 0.136 |
| 7 | Marco Bezzecchi | Pertamina Enduro VR46 | 297.5 | 01:31.229 | 0.544 / 0.026 |
| 8 | Maverick Viñales | Aprilia Racing | 297.5 | 01:31.301 | 0.616 / 0.072 |
| 9 | Fabio Quartararo | Monster Energy Yamaha | 290.3 | 01:31.313 | 0.628 / 0.012 |
| 10 | Jack Miller | Red Bull KTM | 296.7 | 01:31.320 | 0.635 / 0.007 |
| 11 | Brad Binder | Red Bull KTM | 297.5 | 01:31.422 | 0.737 / 0.102 |
| 12 | Aleix Espargaro | Aprilia Racing | 294.2 | 01:31.433 | 0.748 / 0.011 |
| 13 | Pol Espargaro* | Red Bull KTM | 295.8 | 01:31.434 | 0.749 / 0.001 |
| 14 | Miguel Oliveira | Trackhouse Racing | 296.7 | 01:31.724 | 1.039 / 0.290 |
| 15 | Johann Zarco | LCR Honda Castrol | 295.0 | 01:31.735 | 1.050 / 0.011 |
| 16 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 290.3 | 01:31.779 | 1.094 / 0.044 |
| 17 | Alex Rins | Monster Energy Yamaha | 293.4 | 01:31.886 | 1.201 / 0.107 |
| 18 | Alex Marquez | Gresini Racing | 294.2 | 01:31.908 | 1.223 / 0.022 |
| 19 | Augusto Fernandez | GASGAS Tech3 | 295.0 | 01:31.961 | 1.276 / 0.053 |
| 20 | Takaaki Nakagami | LCR Honda Idemitsu | 291.8 | 01:32.208 | 1.523 / 0.247 |
| 21 | Raul Fernandez | Trackhouse Racing | 295.0 | 01:32.227 | 1.542 / 0.019 |
| 22 | Luca Marini | Repsol Honda | 294.2 | 01:32.388 | 1.703 / 0.161 |
| 23 | Stefan Bradl* | HRC Team | 291.8 | 01:33.816 | 3.131 / 1.428 |
*Wild card entry (2)
Note: Repsol Honda rider Joan Mir withdrew from the San Marino Grand Prix due to illness.