Formula 1 Second Free Practice Results Mexico City Mexico Friday October 25
| P | Driver | Team | Lap time | Laps |
| 1 | Carlos Sainz | Scuderia Ferrari | 01:17.699 | 34 |
| 2 | Oscar Piastri | McLaren | 01:17.877 | 30 |
| 3 | Yuki Tsunoda | RB | 01:17.878 | 30 |
| 4 | Charles Leclerc | Scuderia Ferrari | 01:17.887 | 31 |
| 5 | Lando Norris | McLaren | 01:17.948 | 36 |
| 6 | Kevin Magnussen | Haas | 01:18.239 | 34 |
| 7 | Lewis Hamilton | Mercedes | 01:18.279 | 36 |
| 8 | Valtteri Bottas | Kick Sauber | 01:18.351 | 32 |
| 9 | Sergio Perez | Red Bull Racing | 01:18.392 | 32 |
| 10 | Liam Lawson | RB | 01:18.560 | 29 |
| 11 | Fernando Alonso | Aston Martin | 01:18.579 | 35 |
| 12 | Nico Hülkenberg | Haas | 01:18.621 | 34 |
| 13 | Esteban Ocon | Alpine | 01:18.656 | 30 |
| 14 | Lance Stroll | Aston Martin | 01:18.890 | 34 |
| 15 | Franco Colapinto | Williams | 01:18.908 | 30 |
| 16 | Pierre Gasly | Alpine | 01:18.942 | 30 |
| 17 | Zhou Guanyu | Kick Sauber | 01:18.980 | 37 |
| 18 | George Russell | Mercedes | 01:19.041 | 4 |
| 19 | Max Verstappen | Red Bull Racing | no time | 4 |
Note: Williams driver Alexander Albon did not take part in FP2 due to car damage sustained in a crash in FP1.
FP2 was entirely given over to validating the softer compounds in Pirelli’s range for 2025: the C4, C5 and C6.