MotoGP First Free Practice Results Misano San Marino Friday September 12
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Franco Morbidelli | Pertamina Enduro VR46 | 298.3 | 01:31.342 | |
| 2 | Fabio Quartararo | Monster Energy Yamaha | 295.0 | 01:31.591 | 0.249 / 0.249 |
| 3 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 300.8 | 01:31.596 | 0.254 / 0.005 |
| 4 | Alex Marquez | Gresini Racing | 297.5 | 01:31.600 | 0.258 / 0.004 |
| 5 | Marc Marquez | Ducati Lenovo | 300.8 | 01:31.611 | 0.269 / 0.011 |
| 6 | Luca Marini | Honda HRC Castrol | 302.5 | 01:31.613 | 0.271 / 0.002 |
| 7 | Pedro Acosta | Red Bull KTM | 301.6 | 01:31.663 | 0.321 / 0.050 |
| 8 | Marco Bezzecchi | Aprilia Racing | 300.0 | 01:31.675 | 0.333 / 0.012 |
| 9 | Raul Fernandez | Trackhouse Racing | 296.7 | 01:31.809 | 0.467 / 0.134 |
| 10 | Jorge Martin | Aprilia Racing | 300.0 | 01:31.840 | 0.498 / 0.031 |
| 11 | Francesco Bagnaia | Ducati Lenovo | 300.0 | 01:31.929 | 0.587 / 0.089 |
| 12 | Joan Mir | Honda HRC Castrol | 300.0 | 01:31.978 | 0.636 / 0.049 |
| 13 | Jack Miller | Pramac Racing | 297.5 | 01:32.015 | 0.673 / 0.037 |
| 14 | Miguel Oliveira | Pramac Racing | 298.3 | 01:32.017 | 0.675 / 0.002 |
| 15 | Enea Bastianini | KTM Tech3 | 299.1 | 01:32.159 | 0.817 / 0.142 |
| 16 | Fermin Aldeguer | Gresini Racing | 296.7 | 01:32.285 | 0.943 / 0.126 |
| 17 | Maverick Viñales | KTM Tech3 | 295.8 | 01:32.306 | 0.964 / 0.021 |
| 18 | Alex Rins | Monster Energy Yamaha | 295.8 | 01:32.471 | 1.129 / 0.165 |
| 19 | Ai Ogura | Trackhouse Racing | 295.8 | 01:32.509 | 1.167 / 0.038 |
| 20 | Brad Binder | Red Bull KTM | 301.6 | 01:32.510 | 1.168 / 0.001 |
| 21 | Augusto Fernandez* | Yamaha Factory Racing | 292.6 | 01:32.537 | 1.195 / 0.027 |
| 22 | Johann Zarco | Castrol Honda LCR | 299.1 | 01:32.924 | 1.582 / 0.387 |
| 23 | Somkiat Chantra | Idemitsu Honda LCR | 296.7 | 01:33.584 | 2.242 / 0.660 |
*Wild card entry