MotoGP Second Free Practice Results Sepang Malaysia Saturday October 25
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Luca Marini | Honda HRC Castrol | 336.4 | 01:58.415 | |
| 2 | Franco Morbidelli | Pertamina Enduro VR46 | 334.3 | 01:58.422 | 0.007 / 0.007 |
| 3 | Francesco Bagnaia | Ducati Lenovo | 336.4 | 01:58.585 | 0.170 / 0.163 |
| 4 | Joan Mir | Honda HRC Castrol | 338.5 | 01:58.692 | 0.277 / 0.107 |
| 5 | Fermin Aldeguer | Gresini Racing | 333.3 | 01:58.724 | 0.309 / 0.032 |
| 6 | Fabio Quartararo | Monster Energy Yamaha | 332.3 | 01:58.728 | 0.313 / 0.004 |
| 7 | Alex Marquez | Gresini Racing | 335.4 | 01:58.752 | 0.337 / 0.024 |
| 8 | Marco Bezzecchi | Aprilia Racing | 334.3 | 01:58.788 | 0.373 / 0.036 |
| 9 | Johann Zarco | Castrol Honda LCR | 334.3 | 01:58.852 | 0.437 / 0.064 |
| 10 | Pedro Acosta | Red Bull KTM | 340.6 | 01:58.964 | 0.549 / 0.112 |
| 11 | Raul Fernandez | Trackhouse Racing | 329.2 | 01:58.997 | 0.582 / 0.033 |
| 12 | Miguel Oliveira | Pramac Racing | 331.2 | 01:59.196 | 0.781 / 0.199 |
| 13 | Pol Espargaro° | KTM Tech3 | 330.2 | 01:59.302 | 0.887 / 0.106 |
| 14 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 337.5 | 01:59.330 | 0.915 / 0.028 |
| 15 | Jack Miller | Pramac Racing | 336.4 | 01:59.410 | 0.995 / 0.080 |
| 16 | Ai Ogura | Trackhouse Racing | 332.3 | 01:59.489 | 1.074 / 0.079 |
| 17 | Brad Binder | Red Bull KTM | 336.4 | 01:59.506 | 1.091 / 0.017 |
| 18 | Enea Bastianini | KTM Tech3 | 335.4 | 01:59.606 | 1.191 / 0.100 |
| 19 | Lorenzo Savadori~ | Aprilia Racing | 332.3 | 01:59.909 | 1.494 / 0.303 |
| 20 | Alex Rins | Monster Energy Yamaha | 332.3 | 01:59.984 | 1.569 / 0.075 |
| 21 | Somkiat Chantra | Idemitsu Honda LCR | 335.4 | 02:00.616 | 2.201 / 0.632 |
| 22 | Augusto Fernandez* | Yamaha Factory Racing | 328.2 | 02:00.768 | 2.353 / 0.152 |
| 23 | Michele Pirro^ | Ducati Lenovo | 334.3 | 02:01.164 | 2.749 / 0.396 |
*Wild card entry
^Replaced Marc Marquez for the Malaysian Grand Prix
°Replaced Maverick Viñales for the Malaysian Grand Prix
~Replaced Jorge Martin for the Malaysian Grand Prix
Note: Ducati Lenovo rider Marc Marquez (right shoulder injury recovery), Red Bull KTM Tech3's Maverick Viñales (left shoulder injury recovery) and Aprilia Racing rider Jorge Martin (right shoulder injury recovery) were ruled out of the Malaysian Grand Prix.