| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. | |||
|---|---|---|---|---|---|---|---|---|
| 1 | Marc Marquez | Repsol Honda | 333.2 | 02:04.201 | ||||
| 2 | Dani Pedrosa | Repsol Honda | 341.1 | 02:04.658 | 0.457 / 0.457 | |||
| 3 | Maverick Viñales | Movistar Yamaha | 337.1 | 02:04.760 | 0.559 / 0.102 | |||
| 4 | Jack Miller | EG 0,0 Marc VDS | 333.8 | 02:05.213 | 1.012 / 0.453 | |||
| 5 | Cal Crutchlow | LCR Honda | 336.5 | 02:05.368 | 1.167 / 0.155 | |||
| 6 | Johann Zarco | Tech 3 | 336.8 | 02:05.388 | 1.187 / 0.020 | |||
| 7 | Andrea Dovizioso | Ducati | 340.4 | 02:05.438 | 1.237 / 0.050 | |||
| 8 | Loris Baz | Reale Avintia Racing | 334.1 | 02:05.698 | 1.497 / 0.260 | |||
| 9 | Scott Redding | Octo Pramac Racing | 340.3 | 02:05.732 | 1.531 / 0.034 | |||
| 10 | Andrea Iannone | Suzuki Ecstar | 334.9 | 02:05.783 | 1.582 / 0.051 | |||
| 11 | Valentino Rossi | Movistar Yamaha | 336.3 | 02:05.910 | 1.709 / 0.127 | |||
| 12 | Aleix Espargaro | Aprilia Gresini | 330.5 | 02:05.952 | 1.751 / 0.042 | |||
| 13 | Jorge Lorenzo | Ducati | 340.1 | 02:06.032 | 1.831 / 0.080 | |||
| 14 | Jonas Folger | Tech 3 | 332.7 | 02:06.238 | 2.037 / 0.206 | |||
| 15 | Alvaro Bautista | Pull&Bear Aspar | 341.1 | 02:06.484 | 2.283 / 0.246 | |||
| 16 | Tito Rabat | EG 0,0 Marc VDS | 328.8 | 02:06.518 | 2.317 / 0.034 | |||
| 17 | Danilo Petrucci | Octo Pramac Racing | 339.5 | 02:06.521 | 2.320 / 0.003 | |||
| 18 | Pol Espargaro | Red Bull KTM | 332.4 | 02:06.541 | 2.340 / 0.020 | |||
| 19 | Hector Barbera | Reale Avintia Racing | 341.8 | 02:07.238 | 3.037 / 0.697 | |||
| 20 | Karel Abraham | Pull&Bear Aspar | 336.5 | 02:07.565 | 3.364 / 0.327 | |||
| 21 | Sam Lowes | Aprilia Gresini | 323.4 | 02:07.827 | 3.626 / 0.262 | |||
| 22 | Bradley Smith | Red Bull KTM | 327.0 | 02:08.797 | 4.596 / 0.970 |
Note: Team Suzuki Ecstar rider Alex Rins was forced to withdraw from the United States Grand Prix after suffering a left wrist fracture during FP3