MotoGP First Free Practice Results Misano Italy Friday September 20
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Marc Marquez | Gresini Racing | 295.8 | 01:32.082 | |
| 2 | Jorge Martin | Pramac Racing | 297.5 | 01:32.145 | 0.063 / 0.063 |
| 3 | Franco Morbidelli | Pramac Racing | 296.7 | 01:32.268 | 0.186 / 0.123 |
| 4 | Francesco Bagnaia | Ducati Lenovo | 298.3 | 01:32.373 | 0.291 / 0.105 |
| 5 | Maverick Viñales | Aprilia Racing | 295.0 | 01:32.491 | 0.409 / 0.118 |
| 6 | Alex Marquez | Gresini Racing | 295.8 | 01:32.546 | 0.464 / 0.055 |
| 7 | Pedro Acosta | GASGAS Tech3 | 296.7 | 01:32.618 | 0.536 / 0.072 |
| 8 | Brad Binder | Red Bull KTM | 298.3 | 01:32.654 | 0.572 / 0.036 |
| 9 | Fabio Quartararo | Monster Energy Yamaha | 294.2 | 01:32.741 | 0.659 / 0.087 |
| 10 | Jack Miller | Red Bull KTM | 297.5 | 01:32.748 | 0.666 / 0.007 |
| 11 | Miguel Oliveira | Trackhouse Racing | 295.0 | 01:32.823 | 0.741 / 0.075 |
| 12 | Enea Bastianini | Ducati Lenovo | 296.7 | 01:32.825 | 0.743 / 0.002 |
| 13 | Aleix Espargaro | Aprilia Racing | 296.7 | 01:32.910 | 0.828 / 0.085 |
| 14 | Raul Fernandez | Trackhouse Racing | 293.4 | 01:33.133 | 1.051 / 0.223 |
| 15 | Augusto Fernandez | GASGAS Tech3 | 295.0 | 01:33.237 | 1.155 / 0.104 |
| 16 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 294.2 | 01:33.331 | 1.249 / 0.094 |
| 17 | Luca Marini | Repsol Honda | 295.8 | 01:33.390 | 1.308 / 0.059 |
| 18 | Johann Zarco | LCR Honda Castrol | 293.4 | 01:33.430 | 1.348 / 0.040 |
| 19 | Takaaki Nakagami | LCR Honda Idemitsu | 294.2 | 01:33.550 | 1.468 / 0.120 |
| 20 | Joan Mir | Repsol Honda | 295.8 | 01:33.767 | 1.685 / 0.217 |
| 21 | Marco Bezzecchi | Pertamina Enduro VR46 | 297.5 | 01:33.878 | 1.796 / 0.111 |
| 22 | Alex Rins | Monster Energy Yamaha | 288.7 | 01:37.834 | 5.752 / 3.956 |
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