MotoGP Second Free Practice Results Misano Italy Saturday September 21
| P | Rider | Team | Km/h | Lap time | Gap 1st/Prev. |
|---|---|---|---|---|---|
| 1 | Pedro Acosta | GASGAS Tech3 | 301.6 | 01:31.451 | |
| 2 | Fabio Quartararo | Monster Energy Yamaha | 295.8 | 01:31.455 | 0.004 / 0.004 |
| 3 | Francesco Bagnaia | Ducati Lenovo | 300.8 | 01:31.472 | 0.021 / 0.017 |
| 4 | Marc Marquez | Gresini Racing | 300.0 | 01:31.490 | 0.039 / 0.018 |
| 5 | Jorge Martin | Pramac Racing | 302.5 | 01:31.575 | 0.124 / 0.085 |
| 6 | Maverick Viñales | Aprilia Racing | 300.0 | 01:31.725 | 0.274 / 0.150 |
| 7 | Franco Morbidelli | Pramac Racing | 302.5 | 01:31.842 | 0.391 / 0.117 |
| 8 | Enea Bastianini | Ducati Lenovo | 300.8 | 01:31.952 | 0.501 / 0.110 |
| 9 | Raul Fernandez | Trackhouse Racing | 300.0 | 01:32.100 | 0.649 / 0.148 |
| 10 | Brad Binder | Red Bull KTM | 301.6 | 01:32.102 | 0.651 / 0.002 |
| 11 | Aleix Espargaro | Aprilia Racing | 297.5 | 01:32.117 | 0.666 / 0.015 |
| 12 | Augusto Fernandez | GASGAS Tech3 | 298.3 | 01:32.241 | 0.790 / 0.124 |
| 13 | Marco Bezzecchi | Pertamina Enduro VR46 | 302.5 | 01:32.243 | 0.792 / 0.002 |
| 14 | Johann Zarco | LCR Honda Castrol | 297.5 | 01:32.276 | 0.825 / 0.033 |
| 15 | Miguel Oliveira | Trackhouse Racing | 300.0 | 01:32.332 | 0.881 / 0.056 |
| 16 | Luca Marini | Repsol Honda | 297.5 | 01:32.428 | 0.977 / 0.096 |
| 17 | Joan Mir | Repsol Honda | 298.3 | 01:32.438 | 0.987 / 0.010 |
| 18 | Alex Marquez | Gresini Racing | 300.0 | 01:32.474 | 1.023 / 0.036 |
| 19 | Jack Miller | Red Bull KTM | 300.8 | 01:32.505 | 1.054 / 0.031 |
| 20 | Fabio Di Giannantonio | Pertamina Enduro VR46 | 295.8 | 01:32.583 | 1.132 / 0.078 |
| 21 | Takaaki Nakagami | LCR Honda Idemitsu | 296.7 | 01:32.605 | 1.154 / 0.022 |
| 22 | Alex Rins | Monster Energy Yamaha | 296.7 | 01:33.179 | 1.728 / 0.574 |